He has tried many schemes to destroy Christ and to thwart God’s plan of salvation for mankind. He was the tempter of Eve and Adam and still “deceives the whole world” (Revelation 12:9). He led Herod to try to kill Jesus while He was a baby. He tried to tempt Jesus to sin. He stirred up hostility toward Jesus and finally succeeded in getting Him killed. (God and Christ allowed that because it was a part of God’s plan of redemption for mankind.) And it will be Satan who possesses the Beast and the False Prophet at the end of the age and lures the world’s great armies to fight against Christ (Revelation 13:4; Revelation 16:13-14).
Please read Is There Really a Devil? to get much more detail about this evil spirit and his war against humanity.